Fifth, just because it's based off a game doesn't mean it should look like a game with music that sounds like it's in a game. Fourth, since when does speaking cause a blast of air that can push someone down. Third, what attourney worth anything would walk into a courtroom that clueless about the crime. Second, don't say opening statements if you aren't going to follow through. Thank you.įirst of all, that is not at all how any courtroom or trial works, American, Japanese, French, Itallian, any. Freedom of speach and freedom to have my own opinion. There is no requirement that the audience or reviewer has to read the manga, play the game, read the novel, watch the movie, etc, and it is just as important for them to voice their opinion. Regardless of whether it's made for the fans or made as advertisement or made for pure entertainment or whatever, anyone is allowed to watch it. There are no requirements to watch an anime. This review is aimed at others who are in the same position. This review is from the perspective of someone who hasn't played the games and who likes stories to have some kind of logic, real-world or other. My opinion is from the perspective of someone who hasn't played the game and cannot compare it to the game or have prexisting opinions of the story. This review isn't meant for people who have played the games. After watching this, I wouldn't play them even if I did play games. I have a phone that plays solitaire and suduko. I don't even own a game system so it's not even plausable. I HAVE NOT PLAYED THE GAME! Nor do I have any intention to. IMPORTANT!! Before anyone makes anymore stupid comments about this review, I want to make some things very clear.
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Two main histamine metabolic pathways are known in humans, involving the enzymes diamine oxidase (DAO) and histamine-N-methyltransferase (HNMT) ( Figure 2). These wide-ranging physiological effects occur by interaction with four G-protein-coupled receptors with seven transmembrane domains (H1, H2, H3 and H4), which activate signal transduction pathways upon perceiving their ligand, histamine. In addition, histamine functions as a neurotransmitter, being synthesized by neurons located in the posterior region of the hypothalamus whose axons extend through the brain. Functionally, this amine is involved in various immune and physiological mechanisms, stimulating gastric acid secretion, inflammation, smooth muscle cell contraction, vasodilation and cytokine production, among other processes. Specifically, histamine is synthesized and stored in high concentrations in secretory granules, mainly in basophils and mast cells, and also in gastric enterochromaffin cells, lymph nodes and the thymus. The physiological and pathophysiological effects of histamine on the body were first described in 1910 by Dale and Laidlaw, two pioneering researchers who studied the functions of this organic compound at the Wellcome Physiological Research Laboratories. Synthesis of histamine by decarboxylation of its precursor amino acid. This review aims to analyze the pathophysiological relevance of dietary histamine, giving special focus to the adverse effects derived from histamine intake and, in particular, to the state of the art concerning the etiology, diagnosis and treatment of histamine intolerance. 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